Principal Proposed Uses
What Is Hibiscus Used for Today?
1 Adegunloye BJ, Omoniyi JO, Owolabi OA, et al. Mechanisms of the blood pressure lowering effect of the calyx extract of Hibiscus sabdariffa in rats. Afr J Med Med Sci . 1999;25:235–8.
2 Onyenekwe PC, Ajani EO, Ameh DA, et al. Antihypertensive effect of roselle ( Hibiscus sabdariffa ) calyx infusion in spontaneously hypertensive rats and a comparison of its toxicity with that in Wistar rats. Cell Biochem Funct . 1999;17:199–206.
3 Haji Faraji M, Haji Tarkhani A. The effect of sour tea ( Hibiscus sabdariffa ) on essential hypertension. J Ethnopharmacol . 1999;65:231–6.
4 Herrera-Arellano A, Flores-Romero S, Chavez-Soto MA, et al. Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: a controlled and randomized clinical trial. Phytomedicine . 2004;11:375–82.
5 Chang YC, Huang HP, Hsu JD, et al. Hibiscus anthocyanins rich extract-induced apoptotic cell death in human promyelocytic leukemia cells. Toxicol Appl Pharmacol . 2005;205:201–12.
6 Lin HH, Huang HP, Huang CC, et al. Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway. Mol Carcinog . 2005;43:86–99.
7 Adetutu A, Odunola OA, Owoade OA, et al. Anticlastogenic effects of Hibiscus sabdariffa fruits against sodium arsenite-induced micronuclei formation in erythrocytes in mouse bone marrow. Phytother Res . 2004;18:862–4.
8 Tseng TH, Kao TW, Chu CY, et al. Induction of apoptosis by hibiscus protocatechuic acid in human leukemia cells via reduction of retinoblastoma (RB) phosphorylation and Bcl-2 expression. Biochem Pharmacol . 2000;60:307–15.
9 Chewonarin T, Kinouchi T, Kataoka K, et al. Effects of roselle ( Hibiscus sabdariffa Linn.), a Thai medicinal plant, on the mutagenicity of various known mutagens in Salmonella typhimurium and on formation of aberrant crypt foci induced by the colon carcinogens azoxymethane and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in F344 rats. Food Chem Toxicol . 1999;37:591–601.
10 Tseng TH, Hsu JD, Lo MH, et al. Inhibitory effect of Hibiscus protocatechuic acid on tumor promotion in mouse skin. Cancer Lett . 1998;126:199–207.
11 Amin A, Hamza AA. Hepatoprotective effects of Hibiscus , Rosmarinus and Salvia on azathioprine-induced toxicity in rats. Life Sci . 2005;77:266–78.
12 Wang CJ, Wang JM, Lin WL, et al. Protective effect of Hibiscus anthocyanins against tert-butyl hydroperoxide-induced hepatic toxicity in rats. Food Chem Toxicol . 2000;38:411–6.
13 Chen CC, Hsu JD, Wang SF, et al. Hibiscus sabdariffa extract inhibits the development of atherosclerosis in cholesterol-fed rabbits. J Agric Food Chem . 2003;51:5472–7.
14 Chen CC, Chou FP, Ho YC. Inhibitory effects of Hibiscus sabdariffa L extract on low-density lipoprotein oxidation and anti-hyperlipidemia in fructose-fed and cholesterol-fed rats. J Sci Food Agric . 2004;84:1989–96.
15 Kolawole JA, Maduenyi A. Effect of zobo drink ( Hibiscus sabdariffa water extract) on the pharmacokinetics of acetaminophen in human volunteers. Eur J Drug Metab Pharmacokinet . 2004;29:25–9
16 Herrera-Arellano A, Miranda-Sanchez J, Avila-Castro P, et al. Clinical effects produced by a standardized herbal medicinal product of Hibiscus sabdariffa on patients with hypertension: a randomized, double-blind, lisinopril-controlled clinical trial. Planta Med . 2007;73:6-12.
17 Mozaffari-Khosravi H, Jalali-Khanabadi BA, Afkhami-Ardekani M, et al. The effects of sour tea (Hibiscus sabdariffa) on hypertension in patients with type II diabetes. J Hum Hypertens. 2008 Aug 7.
18 Wahabi HA, Alansary LA, Al-Sabban AH, et al. The effectiveness of Hibiscus sabdariffa in the treatment of hypertension: a systematic review. Phytomedicine. 2010 Feb;17(2):83.
- Reviewer: EBSCO CAM Review Board
- Review Date: 07/2012 -
- Update Date: 07/25/2012 -