For older adults with mild cognitive impairment, only diuretics linked to lower risk
WEDNESDAY, Oct. 23 (HealthDay News) -- For older adults, antihypertensive medications are associated with a decreased risk of Alzheimer's disease (AD) dementia, according to research published in the Sept. 3 issue of Neurology.
Sevil Yasar, M.D., Ph.D., from Johns Hopkins University in Baltimore, and colleagues conducted secondary analysis of longitudinal data from older adults, aged 75 years or older from the Ginkgo Evaluation of Memory Study, with normal cognition (1,928 participants) or mild cognitive impairment (320 participants) over a median 6.1-year period.
The researchers found that patients reported taking diuretics (15.6 percent), angiotensin-1 receptor blockers (ARB; 6.1 percent), angiotensin-converting enzyme inhibitors (ACE-I; 15.1 percent), calcium channel blockers (CCB; 14.8 percent), and β-blockers (BB; 20.5 percent). Thirteen percent of the participants developed AD dementia. Among participants with normal cognition, the hazard ratio for development of incident AD dementia was 0.51 in diuretic, 0.31 in ARB, 0.50 in ACE-I, 0.62 in CCB, and 0.58 in BB users. There was no significant alteration in the risk when mean systolic blood pressure was above 140 mm Hg. Only diuretic use was associated with decreased risk among participants with mild cognitive impairment (hazard ratio, 0.38).
"This additional evidence could help the clinician choosing an antihypertensive medication based not only on blood pressure control, but also on additional benefits," the authors conclude.
Several authors disclosed financial ties to the pharmaceutical industry.
Abstract (http://www.neurology.org/content/81/10/896.abstract )Full Text (subscription or payment may be required) (http://www.neurology.org/content/81/10/896.full )Editorial (subscription or payment may be required) (http://www.neurology.org/content/81/10/860.extract )