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Symptoms of End-stage Renal Disease (ESRD)

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The Kidney and Its Main Blood Vessels
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As kidney failure progresses, some of the following symptoms may develop:

  • Loss of appetite
  • Nausea and vomiting
  • Fatigue
  • Weight loss
  • Itchy skin
  • Confusion
  • Trouble concentrating
  • Swelling throughout the body
  • Low urine output
  • Generalized weakness
  • Multiple bruises
  • Numbness and tingling in the extremities
  • Irritability
  • Decreased desire for sexual activity
  • Menstrual irregularities
  • Constipation
  • Diarrhea
  • Muscle cramps and twitches
  • Shortness of breath
  • Chest pain
  • Weak, brittle bones
  • Yellowish-brownish skin tone
  • Headache
  • Frequent hiccups

If kidney failure is untreated, the waste products and fluid that build up can result in:

  • Coma
  • Seizures
  • Death

Revision Information

  • Chronic kidney disease. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed . Updated April 22, 2013. Accessed July 2, 2013.

  • End-stage renal disease. National Institute of Diabetes & Digestive & Kidney Diseases website. Available at: http://www2.niddk.nih.gov/Research/ScientificAreas/Kidney/KEB.htm Updated September 15, 2010. Accessed July 2, 2013.

  • Yu, HT. Progression of chronic renal failure. Arch Int Med . 2003;163:1417-1429.