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Medications for Epilepsy

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The information provided here is meant to give you a general idea about each of the medicines listed below. Only the most general side effects are included. Ask your doctor if you need to take any special precautions. Use each of these medicines as recommended by your doctor, or according to the instructions provided. If you have further questions about usage or side effects, contact your doctor.

Medicines are the first line of treatment for epilepsy . Anti-epileptic medicines should only be used if the diagnosis is established. The goal of medicine is to prevent epileptic seizures and to decrease the frequency and severity of seizures. The type and dosage of medicine given must match the type of epilepsy you have. Dosage is important. It must balance prevention of seizures with the side effects that epileptic drugs can cause.

Often, but not always, one type of medicine is tried at a time until the most effective one is found. Changes in medicine are often made gradually because these changes can increase the likelihood of seizures. Good control is achieved in the majority of people.

In some cases, however, anti-epileptic medicines may be used in combination. In approximately 80% of people, epileptic medicine is fully or partially successful in preventing seizures. Be sure to take the medicine on a regular schedule.

Prescription Medications

Carbamazepine

  • Tegretol
  • Carbatrol

Ethosuximide

  • Zarontin

Gabapentin

  • Neurontin

Lamotrigine

  • Lamictal

Oxcarbazepine

  • Trileptal

Phenytoin

  • Dilantin

Primidone

  • Mysoline

Valproic acid

  • Depakene

Diazepam Rectal Gel

  • Diastat

Vigabatrin

  • Sabril

Phenobarbital

  • Luminal

Topiramate

  • Topamax

Levetiracetam

  • Keppra

Lacosamide

  • Vimpat

Zonisamide

  • Zonegran

Rufinamide

  • Banzel

Tiagabine

  • Gabitril

Clobazam

  • Onfi

Ezogabine

  • Potiga

Carbamazepine

Common brand names include:

  • Tegretol
  • Carbatrol

Carbamazepine prevents seizures by reducing the excitability of nerve fibers in the brain. This medicine is taken as a tablet or liquid. It is best taken at the same time or times each day. Taking carbamazepine with food or drink can help prevent stomach upset.

Possible side effects include:

  • Blurred vision
  • Rapid back and forth eyeball movements
  • Lightheadedness
  • Drowsiness
  • Possible reduced effectiveness of birth control pills—Your doctor will recommend that you use another form of birth control.
  • Interaction with birth control pills—Your doctor may need to adjust your medicine dose.
  • Increased risk of suicidal thinking and behavior

More serious, but less common side effects include:

  • Surpressed bone marrow
  • Rashes
  • Low blood sodium levels
  • Heart failure

According to the Food and Drug Administration (FDA), people of Asian ancestry who have a certain gene, called HLA-B*1502, and take carbamazepine are at risk for dangerous or even fatal skin reactions. If you are of Asian descent, the FDA recommends that you get tested for this gene before taking carbamazepine. If you have been taking this medicine for a few months with no skin reactions, then you are at low risk of developing these reactions. Talk to your doctor before stopping this medicine.

Ethosuximide

Common brand name: Zarontin

Ethosuximide controls seizures by depressing nerve transmissions in the motor cortex, which is the part of the brain that controls muscles. The medicine is taken in liquid or capsule form. It is best taken at the same time or times each day. Taking it with food or drink can help prevent stomach upset.

Possible side effects include:

  • Nausea
  • Appetite loss
  • Vomiting
  • Fatigue
  • Lightheadedness
  • Drowsiness
  • Headache
  • Muscle pain
  • Rash
  • Change in urine color
  • Increased risk of suicidal thinking and behavior

Persistent fever or sore throat should be reported to your doctor. These symptoms may indicate a low white blood cell count due to surpressed bone marrow.

Gabapentin

Common brand name: Neurontin

It is not known how gabapentin prevents convulsive seizures. But, it may work by altering the transport of amino acids in the brain. This medicine is taken in capsule form. Maintenance dosage varies. It is best taken with food or liquid to prevent stomach upset.

Possible side effects include:

  • Sleepiness
  • Lightheadedness
  • Fatigue
  • Lack of coordination
  • Weight gain
  • Rapid back and forth eyeball movements
  • Increased risk of suicidal thinking and behavior

Lamotrigine

Common brand name: Lamictal

It is not known how lamotrigine prevents convulsive seizures. But, it may work by stabilizing nerve membranes. The medicine is taken in tablet form. Maintenance dosage varies. It is best taken with liquid to prevent stomach upset.

When you are taking lamotrigine, call your doctor right away if you have the following symptoms:

  • Rash—can be extremely serious and life-threatening
  • Fever
  • Flu-like symptoms
  • Swollen glands
  • An increase in your seizures

Possible side effects include:

  • Double or blurred vision
  • Clumsiness
  • Lightheadedness
  • Headache
  • Nausea or vomiting
  • Drowsiness
  • Reduced effectiveness of birth control pills—Your doctor will recommend that you use another form of birth control.
  • Increased risk of suicidal thinking and behavior
  • Aseptic meningitis—inflammation of the layers of tissue that surround the brain

Oxcarbazepine

Common brand name: Trileptal

Oxcarbazepine is believed to prevent convulsive seizures by altering the transport of amino acids in the brain and stabilizing the nerve membranes. This medicine is taken in tablet or liquid form. Maintenance dosage varies. It is best taken with liquid.

Possible side effects include:

  • Vision changes
  • Lightheadedness
  • Nausea or vomiting
  • Sleepiness
  • Headache
  • Fatigue
  • Reduced effectiveness of birth control pills—Your doctor will recommend that you use another form of birth control.
  • Increased risk of suicidal thinking and behavior

Phenytoin

Common brand name: Dilantin

Phenytoin prevents seizures by promoting sodium loss in nerve fibers. This inhibits nerve excitability and the spread of nerve impulses. This medicine is taken in tablet or liquid form. It is best taken with liquid at the same time each day.

Possible side effects include:

  • Bleeding
  • Swollen gums
  • Fever
  • Rash
  • Lightheadedness
  • Drowsiness
  • Rapid back and forth eyeball movement
  • Reduced effectiveness of birth control pills—Your doctor will recommend that you use another form of birth control.
  • Increased risk of suicidal thinking and behavior

Primidone

Common brand name: Mysoline

Primidone is believed to prevent seizures by stopping the spread of nerve impulses.

This medicine is taken in tablet or liquid form. It is best taken at the same time each day. It is also best taken with food or drink.

Possible side effects include:

  • Rash
  • Confusion
  • Rapid back and forth eyeball movement
  • Clumsiness
  • Lightheadedness
  • Drowsiness
  • Reduced effectiveness of birth control pills—Your doctor will recommend that you use another form of birth control.
  • Increased risk of suicidal thinking and behavior

Valproic Acid

Common brand name: Depakene

Valproic acid may prevent seizures by increasing concentrations of gamma aminobutyric acid. This inhibits nerve transmissions in parts of the brain. This medicine is taken in capsule or syrup form. It is best taken once a day, at the same time each day. Taking it with food or drink can help prevent stomach upset.

Possible side effects include:

  • Loss of appetite
  • Weight gain
  • Indigestion
  • Nausea or vomiting
  • Diarrhea
  • Tremors
  • Headache
  • Menstrual changes in young women
  • Pancreatitis
  • Liver injury
  • Increased risk of suicidal thinking and behavior

Diazepam Rectal Gel

Common brand name: Diastat

Diazepam is approved for the treatment of people with epilepsy who are affected by seizure clusters. Seizure clusters are multiple seizures that are different from the person's usual pattern. These episodes can last minutes to hours and may require emergency treatment.

Diastat can be given rectally by trained parents or other caregivers in a non-hospital setting.

Possible side effects include:

  • Drowsiness
  • Difficulty breathing
  • Headaches
  • Chemical dependence
  • Increased risk of suicidal thinking and behavior

Vigabatrin

Common brand name: Sabril

Vigabatrin is used to treat seizures in infants aged 1 month to 2 years old. This type of infantile seizure is dangerous because it can happen frequently throughout the day. Vigabatrin can also be used in adults who have refractory complex partial seizures in combination with other anti-seizure medicines.

The medicine can cause serious side effects, including vision loss. Other side effects include:

  • In infants:
    • Sleepiness
    • Weight gain
    • Diarrhea
    • Nausea or vomiting
    • Excitement or agitation
  • In adults:
    • Lightheadedness
    • Sleepiness
    • Weight gain
    • Shakiness
    • Diarrhea
    • Nausea or vomiting
    • Depression
    • Increased risk of suicidal thinking and behavior

Phenobarbital

Common brand name: Luminal

Phenobarbital is used with other anti-epileptic medicines in people who have partial seizures or generalized convulsive seizures. But, the medicine can be prescribed to treat all types of seizures. Phenobarbital is also used for other conditions, such as tremor, insomnia , and drug withdrawal . The medicine has a very long half-life. This means that it stays in your system for a long time. It is available as a pill or given by IV.

Possible side effects include:

  • Depression
  • Sleepiness
  • Lightheadedness
  • Blurred vision
  • Difficulty in thinking clearly
  • Reduced effectiveness of birth control pills—Your doctor will recommend that you use another form of birth control.
  • Increased risk of suicidal thinking and behavior

Phenobarbital is a barbituate, a type of medicine that can be addictive. To avoid withdrawal symptoms, you doctor will slowly reduce the dose when it is time for you to stop taking phenobarbital.

Topiramate

Common brand name: Topamax

Topiramate may be prescribed with other anti-epileptic medicines or alone. The medicine is used to treat all types of seizures. To prevent stomach upset, take topiramate with food.

Possible side effects include:

  • Sleepiness
  • Blurred vision
  • Difficulty thinking clearly
  • Lightheadedness
  • Changes in mood
  • Nausea or vomiting
  • Numbness or tingling in hands or feet
  • Loss of appetite, weight loss
  • Reduced effectiveness of birth control pills—Your doctor will recommend that you use another form of birth control.
  • Depression

More serious, but less common side effects include:

  • Increased risk of suicidal thinking and behavior
  • Glaucoma
  • Kidney stones
  • Acidosis—high acidity in the blood
  • Not sweating enough in hot weather—This causes body temperature to rise.

Levetiracetam

Common brand name: Keppra

Levetiracetam is used to treat partial, generalized convulsive, and myoclonic seizures. The medicine is often prescribed in combination with other anti-epileptic medicine. To prevent stomach upset, take levetiracetam with food.

Possible side effects include:

  • Lightheadedness
  • Sleepiness
  • Blurred vision
  • Difficulty in thinking clearly
  • Changes in mood
  • Nausea or vomiting
  • Headache
  • Cough , runny nose, sore throat
  • Risk of infection
  • Depression
  • Increased risk of suicidal thinking and behavior

Lacosamide

Common brand name: Vimpat

By affecting the central nervous system, this medicine reduces how many seizures a person has and how severe the seizures are. Given as a pill or an injection, lacosamide is usually prescribed with other anti-epileptic medicine.

Possible side effects include:

  • Lightheadedness
  • Sleepiness
  • Blurred vision
  • Difficulty thinking clearly
  • Headache
  • Nausea or vomiting
  • Increased risk of suicidal thinking and behavior

Zonisamide

Common brand name: Zonegran

This medication is a mood stabilizer that works by calming the brain. It is used to prevent or control seizures. It may also be used as a treatment for manic depression .

Possible side effects include:

  • Lightheadedness
  • Sleepiness
  • Blurry vision
  • Unable to think clearly
  • Feeling nervous and excitable
  • Headache
  • Nausea
  • Vomiting
  • Not feeling hungry
  • Serious skin reactions, rarely

Rufinamide

Common brand name: Banzel

This medication is used to treat seizures. It is also especially useful in the treatment of Lennox-Gastaut syndrome.

Possible side effects include:

  • Lightheadedness
  • Sleepiness
  • Blurry vision
  • Unable to think clearly
  • Feeling dizzy
  • Headache
  • Nausea
  • Vomiting

Tiagabine

Common brand name: Gabitril

This medication is used to prevent or control seizures. It is also useful as an add-on treatment for partial seizures.

Possible side effects include:

  • Increased appetite
  • Diarrhea
  • Shakiness
  • Feeling nervous and excitable
  • Lightheadedness
  • Sleepiness
  • Blurry vision
  • Unable to think clearly
  • Feeling dizzy
  • Difficulty moving around
  • Dry mouth
  • Nausea
  • Vomiting

This medicine may rarely cause seizures in patients who do not have them.

Clobazam

Common brand name: Onfi

This medicine is used to control seizures in people with Lennox-Gastaut syndrome, a rare condition that causes severe seizures in childhood.

Possible side effects include:

  • Feeling tired or sleepy
  • Fever
  • Drooling
  • Constipation
  • Cough
  • Urinary tract infection
  • Insomnia
  • Aggression
  • Respiratory infection
  • Irritability
  • Vomiting
  • Problems swallowing
  • Problems with coordination
  • Suicidal thoughts or changes in mood

Ezogabine

Common brand name: Potiga

This medication is used to control seizures in adults with epilepsy. The medicine is often prescribed in combination with other anti-epileptic medicine.

Possible side effects include:

  • Lightheadedness
  • Tiredness or confusion
  • Vertigo —sensation of spinning
  • Tremor
  • Problems with coordination
  • Double vision
  • Attention and memory problems
  • Lack of strength
  • Hallucinations or psychosis
  • Suicidal thoughts or changes in mood
  • Urinary problems

Special Considerations

Before taking any of these medicines, consult with your doctor if you:

  • Have high blood pressure
  • Have heart disease
  • Have glaucoma
  • Have emotional or mental problems
  • Have liver or kidney disease
  • Have a history of blood disorders
  • Have asthma or any other lung disorder
  • Have a blood disorder
  • Have a sodium disorder
  • Will be having any surgery within two months
  • Are taking any other medicines
  • Plan to become pregnant
  • Drink more than two alcoholic drinks per day
  • Have any known allergies

If you are taking medicines, follow these general guidelines:

  • Take your medicine as directed. Do not change the amount or the schedule.
  • Do not stop taking them without talking to your doctor.
  • Do not share them.
  • Use a measuring spoon, cup, or syringe to give the right dose. Make sure it has the same measurements as the medicine. For example, if the medicine is given in milligrams (mg), the device should also say mg.
  • Ask what the results and side effects are. Report them to your doctor.
  • Some drugs can be dangerous when mixed. Talk to a doctor or pharmacist if you are taking more than one drug. This includes over-the-counter medicine and herb or dietary supplements.
  • Plan ahead for refills so you do not run out.

When to Contact Your Doctor

Contact your doctor if you:

  • Have any unusual, rare, or severe symptoms or side effects
  • Suffer any repeat seizures

Revision Information

  • Reviewer: Rimas Lukas, MD
  • Review Date: 03/2013 -
  • Update Date: 00/31/2013 -

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.

Copyright © EBSCO Publishing
All rights reserved.

References

  • Antiepileptic drugs for seizure disorders. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php . Updated February 15, 2013. Accessed February 22, 2013.

  • Berkow R. The Merck Manual of Medical Information. 17th ed. New York, NY: Simon and Schuster; 2000.

  • Dreifuss FE, Rosman NP, Cloyd JC, et al. A comparison of rectal diazepam gel and placebo for acute repetitive seizures. N Engl J Med. 1998;338:1869-1875

  • FDA approves Onfi to treat severe types of seizures. US Food and Drug Administration website. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm276932.htm . Accessed February 22, 2013.

  • Lacosamide. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php . January 18, 2013. Accessed February 22, 2013.

  • Lamotrigine. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php . Updated February 15, 2013. Accessed February 22, 2013.

  • Lennox-Gastaut syndrome . EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php . Updated August 2, 2012. Accessed February 22, 2013.

  • Levetiracetam. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php . Updated February 15, 2013. Accessed February 22, 2013.

  • Myoclonic seizures. Epilepsy Foundation website. Available at: http://www.epilepsyfoundation.org/aboutepilepsy/seizures/genconvulsive/myoclonicseizures.cfm . Accessed February 22, 2013.

  • Phenobarbital. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php . Updated January 18, 2013. Accessed February 22, 2013.

  • Rufinamide. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php . Updated January 18, 2013. Accessed February 22, 2013.

  • Tiagabine. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php . Updated January 18, 2013. Accessed February 22, 2013.

  • Topiramate. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php . Updated January 18, 2013. Accessed February 22, 2013. .

  • Vigabatrin. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php . Updated January 18, 2013. Accessed February 22, 2013.

  • Zonisamide. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php . Updated January 18, 2013. Accessed February 22, 2013.

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  • 11/10/2009 DynaMed's Systematic Literature Surveillance DynaMed's Systematic Literature Surveillance : Sabril approved by FDA to treat spasms in infants and epileptic seizures. US Food and Drug Administration website. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm179855.htm . Updated August 21, 2009. Accessed October 8, 2009.

  • 5/14/2010 DynaMed's Systematic Literature Surveillance DynaMed's Systematic Literature Surveillance : Patorno E, Bohn RL, Wahl PM, Avorn J, Patrick AR, Liu J, Schneeweiss S. Anticonvulsant medications and the risk of suicide, attempted suicide, or violent death. JAMA. 2010;303(14):1401-1409.

  • 8/23/2010 DynaMed's Systematic Literature Surveillance DynaMed's Systematic Literature Surveillance : US Food and Drug Administration. Aseptic meningitis risk with use of seizure drug lamictal. US Food and Drug Administration website. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm222212.htm . Published August 12, 2010. Accessed August 21, 2010.

  • 12/17/2010 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed/what.php : Andersohn F, Schade R, Willich SN, Garbe E. Use of antiepileptic drugs in epilepsy and the risk of self-harm or suicidal behavior. Neurology. 2010;75(4):335-340.

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